Endocrine Abstracts

Background: Mammosomatotroph cell adenoma is rare, accounting for fewer than 2% of all pituitary adenomas and about 8% of tumors associated with acromegaly. A variety of adenomas may present with clinical signs and symptoms of GH hypersecretion including pure GH cell adenomas, mixed GH and prolactin cell adenomas, and monomorphous adenomas with primitive cells able to secrete GH and prolactin including the acidophilic stem cell adenoma and the mammosomatotroph cell adenoma. He...

Background: Non-islet-cell tumor hypoglycemia (NICTH) is a rare but severe complication of malignancy. NICTH has been related to the production of IGF II by tumours of mesenchymal or epithelial origin. It gives rise to frequent episodes of severe hypoglycemia and can have negative impact on quality of life. This case report describes a case of Non Islet cell tumor hypoglycemia due to hepatocellular carcinoma with hypoglycemia as the first presentation.Cl...

Background: Insulin autoimmune syndrome (IAS) or Hirata disease, is a rare cause of hyperinsulinemic hypoglycemia characterized by autoantibodies to endogenous insulin in individuals without previous exposure to exogenous insulin. IAS has been described as a form of type VII hypersensitivity, characterized by the presence of autoantibodies against a circulating antigen. The cornerstone of the IAS is the appearance of circulating insulin autoantibodies (IAA), which have a patho...